6533b853fe1ef96bd12adba0
RESEARCH PRODUCT
Colorectal cancer: An update on the effects of lycopene on tumor progression and cell proliferation
F. CariniS. DavidGiovanni TomaselloM. MazzolaP. DamianiF. RappaL. BattagliaF. CappelloA. JurjusA. Gerges GeageaR. JurjusA. Leonesubject
Settore MED/06 - Oncologia MedicaSettore BIO/11 - Biologia MolecolareNeoplasms ExperimentalCarotenoidsSettore MED/18 - Chirurgia GeneraleLycopeneAnimalsHumanscolorectal cancer antioxidant effects cell proliferationColorectal NeoplasmsReactive Oxygen SpeciesCell ProliferationSignal Transductiondescription
Colorectal cancer (CRC) is one of the most common cancers worldwide. Various factors, including oxidative stress, where excessive productions of reactive oxygen species (ROS) and reactive nitrogen species (RNS) occur, contribute to its pathogenesis. Numerous studies have investigated the effect of antioxidant substances derived from food such as fruits and vegetables; however, data on Lycopene are still rare. Studies on HT-29 colorectal cancer cells and on animal models have shown that lycopene has effects on cell proliferation and on the progression of the CRC by interacting with various cellular signaling pathways. This analysis of the literature focused on the antioxidant effect of lycopene, a substance that is found in the tomato.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-07-08 |