Effect of tormentic acid on insulin secretion in isolated rat islets of langerhans

6533b854fe1ef96bd12addca

RESEARCH PRODUCT

Effect of tormentic acid on insulin secretion in isolated rat islets of langerhans

A. M. Villar M. D. Ivorra Miguel Payá

subject

Pharmacology medicine.medical_specialty geography geography.geographical_feature_category medicine.drug_class Tormentic acid Islet Sulfonylurea In vitro Glibenclamide chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine Insulin secretion Isolated islets medicine.drug

description

Tonnentic acid was isolated as the hypoglycemic agent of Poterium ancistroides Desf. The present study reports effects of this compound on isolated islets of Langerhans. We demonstrate that tormentic acid in the presence of 1.66 mM glucose initiates insulin secretion by isolated rat islets of Langerhans in a dose-dependent fashion at concentrations ranging from 0.05 to 0.5 mM. However, the compound has no effect on the insulin-releasing capacity of 16.6 mM glucose. Similar results were obtained with the sulfonylurea glibenclamide (0.01 mM) used as a reference. These results suggest that the hypoglycemic effect of tormentic acid is due to a diect effect of the compound in vitro.

year	journal	country	edition	language
1989-01-01	Phytotherapy Research

https://doi.org/10.1002/ptr.2650030407

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