Synthesis of tritium labeled 7α-methoxycarbonyl-15β,16β-methylene-3-oxo-17α-pregn-4-ene-21, 17-carbolactone, [3H]SH-D515, a highly selective tracer for the mineralocorticoid receptor

6533b854fe1ef96bd12adea8

RESEARCH PRODUCT

Synthesis of tritium labeled 7α-methoxycarbonyl-15β,16β-methylene-3-oxo-17α-pregn-4-ene-21, 17-carbolactone, [3H]SH-D515, a highly selective tracer for the mineralocorticoid receptor

Kunhard Pollow Hans-jörg Grill Klaus Nickisch Henry Laurent Paul-eberhard Schulze

subject

Aldosterone Chemistry Stereochemistry Organic Chemistry Antagonist Highly selective Biochemistry Analytical Chemistry chemistry.chemical_compound Mineralocorticoid receptor Drug Discovery Radiology Nuclear Medicine and imaging Tritium Methylene Spectroscopy Ene reaction

description

The synthesis of 7α-methoxycarbonyl-15β,16β-methylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone (5, SH-D515, ZK 91587), a potent aldosterone antagonist exhibiting a strong and very selective binding to the mineralocorticoid receptor and the tritiated analog 6 is reported.

year	journal	country	edition	language
1988-02-01	Journal of Labelled Compounds and Radiopharmaceuticals

https://doi.org/10.1002/jlcr.2580250208

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