6533b854fe1ef96bd12adfb2

RESEARCH PRODUCT

Properties of tuberomammillary histamine neurones and their response to galanin.

Dietrich BüsselbergHelmut L. HaasB. Schönrock

subject

medicine.medical_specialtyBath applicationMammillary BodiesImmunologyAction PotentialsGalaninToxicologyMembrane Potentialschemistry.chemical_compoundSlice preparationInternal medicinemedicineAnimalsPharmacology (medical)GalaninNeuronsPharmacologyHistaminergicTuber CinereumResting potentialRatsElectrophysiologyElectrophysiologyEndocrinologymedicine.anatomical_structurenervous systemchemistryBiophysicsPeptidesTuberomammillary nucleusHistamineHistamine

description

Histaminergic neurones in the tuberomammillary nucleus possess electrophysiological properties which distinguish them from other neurones in their neighborhood. Their resting potential is -50 mV and they are spontaneously active at about 2 Hz in a slice preparation. They display a transient outward rectification and an anomalous inward rectification. Bath application of galanin (0.1 microM) reduced their firing rate significantly and hyperpolarized them slightly.

yearjournalcountryeditionlanguage
1991-05-01
http://europepmc.org/abstract/med/1716824