6533b854fe1ef96bd12adfb9

RESEARCH PRODUCT

Wistar rat skin as surrogate for human skin in nortriptyline hydrochloride patch studies

Teresa María GarriguesUlrich SchäferClaus-michael LehrAna Melero

subject

MaleSkin AbsorptionPharmaceutical ScienceHuman skinNortriptylineIn Vitro TechniquesPharmacologyAdministration CutaneousDosage formIn vivoFull thickness skinAnimalsMedicineRats WistarSkinTransdermalChromatographyintegumentary systemEpidermis (botany)business.industryRatsNortriptyline HydrochlorideModels AnimalNortriptylinebusinessmedicine.drug

description

Six different matrices were prepared containing nortriptyline hydrochloride (NTH) with hydroxypropyl-methyl-cellulose as polymer. A mixture of transdermal enhancers was included as part of the vehicle. Diffusion studies were carried out through Wistar rat full thickness skin using Franz cells. They were compared with previously determined human heat separated epidermis in order to test if this animal can be used as model for in vivo assays. A linear correlation was obtained between NTH diffusion coefficients through both skin types (r2=0.996).

yearjournalcountryeditionlanguage
2009-06-03International Journal of Pharmaceutics
https://doi.org/10.1016/j.ijpharm.2009.09.028