Cardiac arrhythmias induced by an electrical stimulation at a cellular level

6533b854fe1ef96bd12ae178

RESEARCH PRODUCT

Cardiac arrhythmias induced by an electrical stimulation at a cellular level

Gabriel Laurent Pierre Athias Sabir Jacquir Stéphane Binczak David Vandroux Jean-marie Bilbault

subject

Fibrillation 0303 health sciences medicine.medical_specialty Chemistry [SDV]Life Sciences [q-bio]Stimulation 030204 cardiovascular system & hematology Cellular level [SPI]Engineering Sciences [physics]03 medical and health sciences Microelectrode 0302 clinical medicine Cellular resolution Internal medicine medicine Biophysics Cardiology Myocyte [NLIN]Nonlinear Sciences [physics]medicine.symptom ComputingMilieux_MISCELLANEOUS 030304 developmental biology

description

To provide insights into the impulse propagation between cardiac myocytes, we performed studies of excitation spread with cellular resolution in confluent monolayers of cultured cardiomyocytes (CM). Multisite field potentials have been recorded using microelectrode arrays (MEA) technology in a basal condition and in proarrhythmic conditions induced by a high frequency electrical stimulation. The in vitro observation of spiral waves opens a new way to test the anti-arrhythmic drugs or strategies at cellular level.

year	journal	country	edition	language
2008-09-14	2008 Computers in Cardiology

https://doi.org/10.1109/cic.2008.4749119

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