6533b854fe1ef96bd12ae90c

RESEARCH PRODUCT

Binding of Cu2+, Zn2+, and Ni(2+)-GnRH complexes with the rat pituitary receptor.

Elzbieta MasiukiewiczAlina GajewskaHenryk Kozo̵wskiKazimierz KochmanHelena KochmanBarbara Rzeszotarska

subject

endocrine systemmedicine.medical_specialtyKineticschemistry.chemical_elementGonadotropin-releasing hormoneZincBiochemistryBinding CompetitiveBuserelinInorganic ChemistryGonadotropin-Releasing HormoneNickelPituitary Gland AnteriorInternal medicinemedicineAnimalsReceptorIncubationChemistryCopperBuserelinRatsKineticsZincEndocrinologyhormones hormone substitutes and hormone antagonistsCopperReceptors LHRHmedicine.drugHormone

description

Complex of copper with the gonadotropin-releasing hormone, GnRH, competed more efficiently for the GnRH receptor than native GVRH, while complexes of nickel with GnRH and zinc with GnRH had slightly lower affinity. Copper ion added to the incubation mixture inhibited the buserelin binding to the receptor.

yearjournalcountryeditionlanguage
1997-03-01Journal of inorganic biochemistry
10.1016/s0162-0134(96)00143-2https://pubmed.ncbi.nlm.nih.gov/9046108