Effect of DB-c-AMP on mechanical characteristics of ventricular and atrial preparations of several mammalian species

6533b854fe1ef96bd12ae920

RESEARCH PRODUCT

Effect of DB-c-AMP on mechanical characteristics of ventricular and atrial preparations of several mammalian species

Hermann Nawrath H. Scholz K. Winter Thomas Meinertz

subject

Inotrope medicine.medical_specialty Time Factors Heart Ventricles Guinea Pigs Pharmacology toxicology Isometric exercise Species Specificity Internal medicine medicine Animals Heart Atria Electric stimulation Pharmacology Sheep Bucladesine CATS business.industry Organ Size General Medicine Papillary Muscles Electric Stimulation Stimulation Chemical C++ AMP Rats Endocrinology Bucladesine Cats Cattle Rabbits business Heart atrium medicine.drug

description

Conflicting results exist about the influence of cyclic N6-2′-O-dibutyryl-AMP (DB-c-AMP) on myocardial contractile force. The present study was designed to examine whether the positive inotropic action of DB-c-AMP is restricted to certain model preparations or whether it can be assumed to represent a more general effect of the drug. Therefore, the effects of DB-c-AMP on myocardial force and on various parameters of the isometric contraction curve were examined in isolated electrically driven (0.5–2Hz) ventricular and atrial preparations of several mammalian species (cat, rabbit, calf, sheep, rat and guinea-pig). The following results were obtained:

year	journal	country	edition	language
1974-04-05	Naunyn-Schmiedeberg's Archives of Pharmacology

https://doi.org/10.1007/bf00499029

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