6533b854fe1ef96bd12ae997

RESEARCH PRODUCT

Studies on the mechanism of PMN activation III. by lymphokines.

U. BotzenhardtE. M. LemmelJ. Müller

subject

medicine.medical_specialtyNeutrophilsGuinea PigsBiologyLymphocyte ActivationGuinea pigPeritoneal cavitychemistry.chemical_compoundInternal medicinemedicineMigration inhibitionAnimalsAscitic FluidHumansLymphokinesOxidative metabolismGlycogenZymosanLymphokineZymosanHematologyGeneral MedicineRespiratory burstEndocrinologymedicine.anatomical_structurechemistryCell Migration InhibitionCell DivisionThymidine

description

The influence of a guinea pig lymphokine preparation on the oxidative metabolism of human and guinea pig granulocytes of various sources was investigated. A dose-dependent increase of the oxidative burst following lymphokine challenge was observed. It occurred in unstimulated guinea pig peripheral polymorphonuclear leukocytes (PMN) and in prestimulated PMN obtained from the peritoneal cavity after glycogen injection as well. The lymphokine effect on the oxidative metabolism is not species-restricted because the guinea pig lymphokine preparation elicits an oxidative burst in human PMN, too. The increase caused by lymphokines is nearly of the same order of magnitude as that obtained with zymosan.

yearjournalcountryeditionlanguage
1983-03-01Blut
10.1007/bf00320274https://pubmed.ncbi.nlm.nih.gov/6824796