6533b854fe1ef96bd12aea0b
RESEARCH PRODUCT
Challenges in the pharmacological treatment of geriatric asthma
Mario SpataforaScichilone NicolaSalvatore BattagliaFabio AgustaAlida Benfantesubject
Agingmedicine.medical_specialtyComplex diseaseComorbidityDiseaseSettore MED/10 - Malattie Dell'Apparato RespiratorioAnti-asthmatic AgentPharmacological treatmentOlder population03 medical and health sciences0302 clinical medicineMultidisciplinary approachAnimalsHumansMedicinePharmacology (medical)Anti-Asthmatic Agents030212 general & internal medicineGeneral Pharmacology Toxicology and PharmaceuticsIntensive care medicinePsychiatryAgedAsthmabusiness.industryAge FactorsGeneral Medicinemedicine.diseaseComorbidityAsthmaInhaled treatment030228 respiratory systemAdherencePharmacology Toxicology and Pharmaceutics (all)businessdescription
ABSTRACTAsthma in older populations is characterized by frequent comorbid conditions, which increase the risk of side effects and of detrimental interactions between respiratory and non-respiratory drugs. These observations lead to the need to manage asthma in older populations by applying a multidimensional assessment and a multidisciplinary treatment; therefore, we favor the use of the ‘geriatric’ term to define asthma in the elderly. Geriatric asthma is a complex disease, which may not necessarily imply that it is also complicated, although the two conditions may often coexist. On this basis, the switch from an organ-driven management to the holistic approach may be the key factor to attain optimal control of the disease in this age range. The current review discusses the age-related factors affecting asthma treatment in the oldest individuals, such as the comorbid conditions, and age-related changes of metabolism and excretion that can impair the efficacy and safety of drugs.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-03-18 | Expert Review of Clinical Pharmacology |