Inhibition of calcium entry induced by cularines and isocrasifoline in uterine smooth muscle.

6533b854fe1ef96bd12aeaf1

RESEARCH PRODUCT

Inhibition of calcium entry induced by cularines and isocrasifoline in uterine smooth muscle.

Luis Castedo Pilar D'ocon Carmen Vulaverde Dolores Ivorra Rafael Blasco Susana López Diego Cortes Luz Candenas

subject

medicine.medical_specialty Nifedipine In Vitro Techniques Oxytocin chemistry.chemical_compound Uterine Contraction Alkaloids Nifedipine Coumarins Internal medicine Papaverine medicine Animals Vanadate Benzylisoquinoline Pharmacology Papaverine Chemistry Alkaloid Muscle Smooth Rats Inbred Strains Isoquinolines Rats Endocrinology Oxytocin Mechanism of action Calcium Female medicine.symptom Vanadates medicine.drug Muscle contraction Muscle Contraction

description

Abstract The effects of nifedipine, papaverine and four benzylisoquinoline alkaloids (cularine, cularidine, celtisine and isocrasifoline) were studied in isolated rat uterus in order to clarify the mechanism of their relaxant action. All the compounds tested completely relaxed KCl-induced contractions and totally or partially inhibited oxytocin-induced rhythmic contractions. Only papaverine acted intracellularly, promoting relaxation of contractile responses induced by oxytocin or vanadate in a Ca 2+ -free medium. In spite of the structural relationship between papaverine and the other alkaloids, the mechanism of their relaxant action is not the same. The activities of cularine derivatives and of isocrasifoline were similar to that of nifedipine.

year	journal	country	edition	language
1991-04-17	European journal of pharmacology

10.1016/0014-2999(91)90426-q https://pubmed.ncbi.nlm.nih.gov/1874285

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