6533b854fe1ef96bd12aeb59
RESEARCH PRODUCT
Selenoprotein synthesis and side-effects of statins.
Bernd MoosmannChristian Behlsubject
medicine.medical_specialtyHypercholesterolemiaCoronary DiseaseBioinformaticsModels BiologicalRhabdomyolysisPolyneuropathiesSeleniumMuscular DiseasesSelenium deficiencyInternal medicinemedicineHumanscardiovascular diseasesSelenium metabolismMyopathySelenoproteinschemistry.chemical_classificationbusiness.industrynutritional and metabolic diseasesProteinsGeneral Medicinemedicine.diseaseCoronary heart diseaseEndocrinologychemistryProteins metabolismProtein Biosynthesislipids (amino acids peptides and proteins)Selenoproteinmedicine.symptomHydroxymethylglutaryl-CoA Reductase InhibitorsbusinessRhabdomyolysisPolyneuropathydescription
Statins are possibly the most effective drugs for the prevention and treatment of hypercholesterolaemia and coronary heart disease. They are generally well tolerated, however, they do cause some unusual side-effects with potentially severe consequences, most prominently myopathy or rhabdomyolysis and polyneuropathy. We noted that the pattern of side-effects associated with statins resembles the pathology of selenium deficiency, and postulated that the mechanism lay in a well established, but often overlooked, biochemical pathway--the isopentenylation of selenocysteine-tRNA([Ser]Sec). A negative effect of statins on selenoprotein synthesis does seem to explain many of the enigmatic effects and side-effects of statins, in particular, statin-induced myopathy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-03-20 | Lancet (London, England) |