6533b854fe1ef96bd12aeb8e
RESEARCH PRODUCT
Effects of Antidepressants on Inhibitory Avoidance in Mice: A Review
Santiago MonleónAndrés ParraConcepción Vinader-caerolssubject
Drugmedicine.medical_specialtyGeneralized anxiety disorderbusiness.industrymedia_common.quotation_subjectChronic painmedicine.diseaseMechanism of actionEnuresismedicineAnxietymedicine.symptombusinessPsychiatryDepression (differential diagnoses)media_commonAgoraphobiadescription
Neither the biological basis of depression (Nemeroff & Vale, 2005; Kasper & McEwen, 2008) nor the precise mechanism of antidepressant efficacy are completely understood (Dudra-Jastrzebska et al., 2007). Indeed, antidepressants are widely prescribed for anxiety and disorders other than depression. For example, they are the drug therapy of choice for severe anxiety disorders such as agoraphobia, generalized anxiety disorder, social phobia, obsessive-compulsive disorder and post-traumatic stress disorder (Baldessarini, 2001). Antidepressants are also employed as a therapeutic tool in disorders such as drug addition (e.g. Schatzberg, 2000), enuresis (e.g. Humphreys & Reinberg, 2005) and chronic pain (e.g. Sindrup et al., 2005). This wide application of the effects of antidepressants and the heterogeneity of their mechanism of action suggest the existence of a common therapeutic mechanism among the disorders which these drugs are employed to treat.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-06-29 |