6533b854fe1ef96bd12aebf0

RESEARCH PRODUCT

CAR-T therapy in solid transplant recipients with post-transplant lymphoproliferative disease: case report and literature review

Juan Carlos Hernández-boludaAriadna PérezRafael HernaniMaría José TerolPaula AmatBlanca FerrerCarlos SolanoAna SausJosé Luis PiñanaRosa GoterrisAna Isabel TeruelCarlos CarreteroMontse GómezAsunción Sancho

subject

Oncologymedicine.medical_specialtymedicine.medical_treatmentImmunotherapy AdoptiveGeneral Biochemistry Genetics and Molecular BiologyRefractoryhemic and lymphatic diseasesInternal medicinemedicineHumansKidneyReceptors Chimeric Antigenbusiness.industryImmunosuppressionOrgan TransplantationGeneral MedicineLymphoproliferative DisordersTransplant RecipientsChimeric antigen receptorDiscontinuationsurgical procedures operativemedicine.anatomical_structureConcomitantRituximabLymphoproliferative diseasebusinessmedicine.drug

description

Patients with postransplant lymphoproliferative disease (PTLD) who are refractory to rituximab-based regimens have extremely poor prognosis. Data is lacking in the setting of solid organ transplantation (SOT)-related PTLD treated with chimeric antigen receptor T-cell (CAR-T) therapy. Moreover, limited information is available on the influence of concomitant immunosuppressive drugs on CAR-T function. Here, we describe the clinical outcome in one PTLD patient and propose a strategy for tailoring immunosuppressive treatment and organ monitoring in patients with kidney allografts after CAR-T infusion. This report also reviews the limited published data in the setting of SOT-related PTLD treated with CAR-T, which appears to be a feasible treatment in this clinical scenario, without severe toxicity and capable of inducing sustained responses. A noteworthy finding is that in most reported cases patients underwent complete or partial discontinuation of immunosuppressive drugs, with only one documented case of allograft rejection.

yearjournalcountryeditionlanguage
2021-04-05Current Research in Translational Medicine
https://doi.org/10.1016/j.retram.2021.103304