6533b854fe1ef96bd12aec8e

RESEARCH PRODUCT

Effect of tin and lead chlorotriphenyl analogues on fruit fly Drosophila hydei and liposomes membrane

Sławomir MitrusDariusz Man

subject

Triphenyltin chlorideHealth Toxicology and MutagenesisToxicologyBiochemistryChloridechemistry.chemical_compoundOrganometallic CompoundsOrganotin CompoundsmedicineAnimalsLipid bilayerMolecular BiologyDrosophilaLiposomeTriphenylmethanebiologyCell MembranefungiElectron Spin Resonance SpectroscopyTrityl CompoundsGeneral Medicinebiology.organism_classificationMembraneLeadBiochemistrychemistryTinLiposomesModels AnimalDrosophila hydeiMolecular MedicineDrosophilamedicine.drug

description

This article presents the results of a study investigating the biological activity of triphenyltin chloride (TPhT) and two metalloorganic compounds, triphenyllead chloride (TPhL) and triphenylmethane chloride (TPhC), in their interaction with model membranes and the living organisms of fruit flies Drosophila hydei. The study of model membranes (sonicated liposomes) was conducted using the electron spin resonance (ESR) spin probe technique, whereas the experiment on fruit flies involved investigating their viability on media containing the studied compounds. The test results clearly demonstrate that TPhT affects fruit flies more actively than TPhL (complete lethality after 7 days of culture with a TPhT-containing medium). No toxic effect of TPhC on fruit flies was shown. The results of the biological experiment were reflected in the physical experiment involving an ESR study of liposomes: TPhT activity manifested itself as a considerable increase in fluidity of the central region of the liposome lipid bilayer.

yearjournalcountryeditionlanguage
2011-10-03Journal of Biochemical and Molecular Toxicology
https://doi.org/10.1002/jbt.21403