Metformīna ierosinātas izmaiņas gēnu ekspresijas profilos otrā tipa cukura diabēta pacientos

6533b854fe1ef96bd12aee38

RESEARCH PRODUCT

Metformīna ierosinātas izmaiņas gēnu ekspresijas profilos otrā tipa cukura diabēta pacientos

subject

transkriptoms metformīns 2. tipa cukura diabēts Bioloģija diferenciāli ekspresēti gēni

description

Metformīns ir pirmās izvēles medikaments 2. tipa cukura diabēta ārstēšanā, tā terapeitiskais efekts ir pierādīts ļaundabīgo audzēju un neirodeģeneratīvu slimību ārstēšanā. Metformīnam ir raksturīga variabla efektivitāte, turklāt medikamenta darbības mehānisms joprojām nav skaidrs. Pētījuma ietvaros tika veikta uz nākamās paaudzes sekvencēšanu balstīta asins šūnu transkriptoma analīze 17 eiropeiskas izcelsmes 2. tipa cukura diabēta pacientiem pirms metformīna terapijas uzsākšanas un pēc trīs mēnešus ilgas metformīna lietošanas. Rezultāti liecina, ka metformīns statistiski nozīmīgi izmaina 28 gēnu ekspresijas līmeni 2. tipa cukura diabēta pacientu asins šūnās, turklāt tā ietekme uz šūnu signālceļiem ir saistīta ar organisma imūnreakcijām un enerģijas metabolismu, kas sakrīt ar iepriekš aprakstītiem metformīna terapeitiskajiem efektiem.

year	journal	country	edition	language
2019-01-01

https://dspace.lu.lv/dspace/handle/7/47268

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