6533b854fe1ef96bd12af2e2
RESEARCH PRODUCT
Composition en acides gras des hémisphères cérébraux de rats spontanément hypertendus allaités par des femelles Wistar
Jean-pierre PoissonVéronique FustierJean-luc SavelliMichel Narcesubject
medicine.medical_specialtyBrain chemistryGeneral Immunology and MicrobiologyCentral nervous systemGeneral MedicineBiologyGeneral Biochemistry Genetics and Molecular Biologymedicine.anatomical_structureEndocrinologyAnimal modelInternal medicineCerebral hemispheremedicineStandard dietWeaningFatty acid compositionWistar Kyoto RatsGeneral Agricultural and Biological Sciencesdescription
Total lipid fatty acid composition was investigated in brain hemispheres of male Spontaneously Hypertensive Rats (SHR), compared with normotensive Wistar Kyoto rats (WKY) used as controls. Both strains were suckled by adoptive Wistar mothers, and then fed a standard diet after weaning. No difference was observed between the two hemispheres of WKY killed either at 10 or 30 days. In SHR killed at 10 days, the two hemispheres showed differences, SHR left hemispheres exhibiting greater fatty acid composition changes than those of WKY, phenomenon that toned down at 30 days. Hence, SHR pups showed a different total lipid fatty acid composition of their brain hemispheres when compared with their WKY controls, though the two strains received the same diet. Genetically programmed hypertension might be, directly or not, involved in these changes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-06-01 | Comptes Rendus Biologies |