0000000000321117

AUTHOR

Jean-luc Savelli

showing 2 related works from this author

Dietary fish protein lowers blood pressure and alters tissue polyunsaturated fatty acid composition in spontaneously hypertensive rats.

2003

Abstract Objectives To investigate the effect of two types of dietary protein on blood pressure, liver fatty acid desaturation and composition, and urine 6-keto-prostaglandin-F (PGF1α) level, the metabolite of prostacyclin. Methods 5-wk-old spontaneously hypertensive rats were fed 20% casein or purified fish protein. The fat source was 5% ISIO oil, which contains 47.9% (ω-6) and 1.7% (ω-3) total polyunsaturated fatty acids. After 2 mo on the diet, systolic blood pressure was reduced with fish protein compared with casein (189.8 ± 10.5 versus 220.7 ± 8.7). Results Excretion of 6-keto-PGF1α in urine was negatively correlated with blood pressure. Liver cholesterol and phospholipid concentratio…

Fatty Acid DesaturasesFish ProteinsMalemedicine.medical_specialtyEndocrinology Diabetes and MetabolismMetabolitePhospholipidBlood PressureUrine6-Ketoprostaglandin F1 alphaBiologyExcretionchemistry.chemical_compoundDietary Fats UnsaturatedInternal medicineCaseinRats Inbred SHRmedicineAnimalsAntihypertensive Agentschemistry.chemical_classificationNutrition and DieteticsBody WeightProstaglandins FCaseinsLipid metabolismOrgan SizeLipid MetabolismLipidsRatsBlood pressureEndocrinologychemistryLiverHypertensionFatty Acids UnsaturatedMicrosomes LiverDietary ProteinsPolyunsaturated fatty acidNutrition (Burbank, Los Angeles County, Calif.)
researchProduct

Composition en acides gras des hémisphères cérébraux de rats spontanément hypertendus allaités par des femelles Wistar

2003

Total lipid fatty acid composition was investigated in brain hemispheres of male Spontaneously Hypertensive Rats (SHR), compared with normotensive Wistar Kyoto rats (WKY) used as controls. Both strains were suckled by adoptive Wistar mothers, and then fed a standard diet after weaning. No difference was observed between the two hemispheres of WKY killed either at 10 or 30 days. In SHR killed at 10 days, the two hemispheres showed differences, SHR left hemispheres exhibiting greater fatty acid composition changes than those of WKY, phenomenon that toned down at 30 days. Hence, SHR pups showed a different total lipid fatty acid composition of their brain hemispheres when compared with their W…

medicine.medical_specialtyBrain chemistryGeneral Immunology and MicrobiologyCentral nervous systemGeneral MedicineBiologyGeneral Biochemistry Genetics and Molecular Biologymedicine.anatomical_structureEndocrinologyAnimal modelInternal medicineCerebral hemispheremedicineStandard dietWeaningFatty acid compositionWistar Kyoto RatsGeneral Agricultural and Biological SciencesComptes Rendus Biologies
researchProduct