Burden and viral aetiology of influenza-like illness and acute respiratory infection in intensive care units

6533b854fe1ef96bd12af379

RESEARCH PRODUCT

Burden and viral aetiology of influenza-like illness and acute respiratory infection in intensive care units

Emanuele Amodio Vitale Francesco Casuccio Alessandra Carmelo Massimo Maida Caterina Mammina Fabio Tramuto Giuseppe Napoli Cinzia Calà

subject

Male Pediatrics Settore MED/42 - Igiene Generale E Applicata law.invention 0302 clinical medicine law Influenza-like illness 030212 general & internal medicine Child Sicily Respiratory Tract Infections Acute respiratory tract infection Aged 80 and over Intensive care units Respiratory tract infections Coinfection Mortality rate Age Factors Respiratory infection Middle Aged Intensive care unit Co-infection Co-infection; Influenza-like illness; Intensive care units; Italy; Sicily; Viral infection; Microbiology; Immunology; Infectious Diseases Infectious Diseases Italy Virus Diseases Child Preschool Coinfection Female Adult medicine.medical_specialty Adolescent Immunology Microbiology Article Young Adult 03 medical and health sciences Intensive care medicine Humans Intensive care unit Retrospective Studies Influenza-like illne Influenza-like illness business.industry Infant Newborn Infant medicine.disease Survival Analysis Cross-Sectional Studies 030228 respiratory system Viral infection business

description

The purpose of this investigation was to study the viral aetiology of influenza-like illness (ILI) and acute respiratory tract infection (ARTI) among patients requiring intensive care unit admission. A cross-sectional retrospective study was carried out in Sicily over a 4-year period. A total of 233 respiratory samples of patients with ILI/ARTI admitted to intensive care units were molecularly analyzed for the detection of a comprehensive panel of aetiologic agents of viral respiratory infections. About 45% of patients was positive for at least one pathogen. Single aetiology occurred in 75.2% of infected patients, while polymicrobial infection was found in 24.8% of positive subjects. Influenza was the most common aetiologic agent (55.7%), especially among adults. Most of patients with multiple aetiology (76.9%) were adults and elderly. Mortality rates among patients with negative or positive aetiology did not significantly differ (52.4% and 47.6%, respectively). Highly transmissible respiratory pathogens are frequently detected among patients with ILI/ARTI admitted in intensive care units, showing the occurrence of concurrent infections by different viruses. The knowledge of the circulation of several types of microorganisms is of crucial importance in terms of appropriateness of therapies, but also for the implication in prevention strategies and hospital epidemiology.

year	journal	country	edition	language
2015-12-17	Microbes and Infection

https://doi.org/10.1016/j.micinf.2015.11.008