6533b854fe1ef96bd12af3f6
RESEARCH PRODUCT
Preparation and physico-chemical study of inclusion complexes between idebenone and modified beta-cyclodextrins
Giovanni PuglisiM. ZappalaMaria Angela VandelliMassimo FrestaCa VenturaGennara Cavallarosubject
dissolution studyAqueous solutioncyclodextrinsChemistryCoprecipitationtechnology industry and agricultureGeneral ChemistryNuclear magnetic resonance spectroscopyCondensed Matter Physicscyclodextrins; idebenone; characterization of complexes; dissolution studycarbohydrates (lipids)idebenonecharacterization of complexesDifferential scanning calorimetrypolycyclic compoundsmedicineIdebenoneOrganic chemistrylipids (amino acids peptides and proteins)Free drugInclusion (mineral)DissolutionFood Sciencemedicine.drugNuclear chemistrydescription
The inclusion properties of modifiedβ-cyclodextrins (trimethyl-β-cyclodextrin, dimethyl-β-cyclodextrin and hydroxypropyl-β-cyclodextrin) towards idebenone were compared with naturalβ-cyclodextrin. The inclusion complexes were prepared by different methods (coprecipitation, kneading, and freeze-drying) and characterized by differential scanning calorimetry, X-ray diffractometry, UV, CD and NMR spectroscopy. The results obtained by CD and NMR spectroscopy indicate a different orientation of idebenone in dimethyl-β-cyclodextrin with respect to other cyclodextrins. Stability constants of the complexes were determined in water at various temperatures and consequently thermodynamic parameters were obtained. All cyclodextrins are able to significantly increase the water solubility of idebenone, particularly dimethyl-β-cyclodextrin and hydroxypropyl-β-cyclodextrin, as a result of complexation. Consequently, they enhance the dissolution rate of the complexed drug compared to the free drug.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-01-01 |