Divide and rule: The role of ubiquitination in inactivation of the ERK5-MAPK cascade

6533b854fe1ef96bd12af45f

RESEARCH PRODUCT

Divide and rule: The role of ubiquitination in inactivation of the ERK5-MAPK cascade

Katharina Schulenburg Attila Reményi Gábor Glatz Krishnaraj Rajalingam

subject

MAPK/ERK pathway Inhibitor of apoptosis domain Cancer Research Akt/PKB signaling pathway Chemistry MAPK cascade Inhibitor of apoptosis MAP2K7 XIAP Cell biology Cancer research Molecular Medicine Author's View Protein kinase B

description

Recently, we revealed that ubiquitination of MEKK2 and MEKK3 by inhibitor of apoptosis proteins (IAPs) directly disrupts MEK5/ERK5 interaction and subsequently attenuates ERK5 activation. In addition, loss of XIAP promotes human myogenic differentiation in an ERK5-dependent manner. These results reveal another layer of MAPK regulation and a novel role for XIAP in controlling myogenic differentiation.

year	journal	country	edition	language
2014-11-11	Molecular & Cellular Oncology

https://doi.org/10.4161/23723548.2014.969170

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