6533b854fe1ef96bd12af527

RESEARCH PRODUCT

Medication-related osteonecrosis of the jaws (MRONJ) in cancer patients treated with denosumab VS. zoledronic acid : a systematic review and meta-analysis

Alvaro LimonesMichael M. BornsteinSantiago Angulo Díaz-parreñoLuis Miguel Sáez-alcaidePedro Molinero-mourelleAlexandra Helm

subject

medicine.medical_specialtymedication-related osteonecrosis of the jawsPHASE-3SKELETAL-RELATED EVENTSneoplasmsbisphosphonate-associated osteonecrosis of the JawsReviewBREASTZoledronic AcidDISEASElaw.invention03 medical and health scienceszoledronic acidDOUBLE-BLIND0302 clinical medicineRandomized controlled triallawInternal medicineNeoplasmsDentistry Oral Surgery & MedicinemedicineHumansGeneral DentistryRISKBONE METASTASESBisphosphonate-associated osteonecrosis of the jawScience & TechnologyOral Medicine and PathologyBone Density Conservation AgentsDiphosphonatesbusiness.industryIncidence (epidemiology)030206 dentistryOdds ratiomedicine.disease:CIENCIAS MÉDICAS [UNESCO]DenosumabZoledronic acidOtorhinolaryngologyMeta-analysisRelative riskUNESCO::CIENCIAS MÉDICASSurgeryBisphosphonate-Associated Osteonecrosis of the JawDenosumabbusinessLife Sciences & Biomedicinemedicine.drug

description

Background The aim of the present study was to analyse the incidence, risk ratio (RR) and prognoses of two types of medication-related osteonecrosis of the jaws (MRONJ): denosumab-related osteonecrosis of the jaws (DRONJ) and Bisphosphonate-Related Osteonecrosis of the Jaws (BRONJ) in cancer patients under treatment with denosumab or zoledronic acid (ZA). Material and Methods An electronic and manual search was conducted for randomized controlled trials (RCTs) until May 2019. Assessment of the identified studies, risk of bias and data extraction were performed independently by two reviewers. The incidence of DRONJ and BRONJ and the RR to develop MRONJ were calculated at 1 year, 2 years and 3 years of exposure. It was also calculated the odds ratio (OR) of their respective prognoses. They were calculated normalizing the values of the individual studies to 1 year, 2 years or 3 years when necessary through robust regression models using a statistical program. Results From 1.277 references identified, 8 RCTs were included, which comprised a total of 13.857 patients with a variety of neoplasms. The incidence of DRONJ in cancer patients under treatment with denosumab ranged from 0.5 to 2.1% after 1 year, 1.1 to 3.0% after 2 years, and 1.3 to 3.2% after 3 years of exposure. The incidence of BRONJ in cancer patients under treatment with ZA ranged from 0.4 to 1.6% after 1 year of exposure, 0.8 to 2.1% after 2 years, and 1.0 to 2.3% after 3 years of exposure. Statistically significant differences were found between denosumab and ZA in the risk of developing MRONJ after 1, 2 and 3 years of exposure. Nevertheless, there were no significant differences in terms of patient prognosis. Conclusions Denosumab is associated with a significantly higher risk of developing MRONJ compared to ZA. Nevertheless, no differences were found in its prognoses. Key words:Denosumab, zoledronic acid, bisphosphonate-associated osteonecrosis of the Jaws, medication-related osteonecrosis of the jaws, neoplasms.

yearjournalcountryeditionlanguage
2020-01-01
10.4317/medoral.23324https://hdl.handle.net/10550/77133