6533b854fe1ef96bd12af571
RESEARCH PRODUCT
Is the Macrophage Phenotype Determinant for Fibrosis Development?
Jesus Cosin-rogerC BausetMarta Seco-cerveraLluis Lis-lópezsubject
Lungpulmonary fibrosisQH301-705.5business.industryCardiac fibrosiscardiac fibrosiskidney fibrosisMedicine (miscellaneous)Connective tissueReviewmedicine.diseasePhenotypeGeneral Biochemistry Genetics and Molecular BiologymacrophagesExtracellular matrixmedicine.anatomical_structureFibrosisPulmonary fibrosisintestinal fibrosisCancer researchmedicineMacrophageBiology (General)businessliver fibrosisdescription
Fibrosis is a pathophysiological process of wound repair that leads to the deposit of connective tissue in the extracellular matrix. This complication is mainly associated with different pathologies affecting several organs such as lung, liver, heart, kidney, and intestine. In this fibrotic process, macrophages play an important role since they can modulate fibrosis due to their high plasticity, being able to adopt different phenotypes depending on the microenvironment in which they are found. In this review, we will try to discuss whether the macrophage phenotype exerts a pivotal role in the fibrosis development in the most important fibrotic scenarios.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-11-01 | Biomedicines |