6533b855fe1ef96bd12afd9a

RESEARCH PRODUCT

Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood

Fabienne PeléUlrike GehringCarolina Moltó-puigmartíMarin StrømMarin StrømTanja G. M. VrijkotteEmily OkenCostanza PizziManolis KogevinasLeda ChatziLeda ChatziHenrique BarrosMartine VrijheidMaurice P. ZeegersTheano RoumeliotakiJordi SunyerSian M. RobinsonSian M. RobinsonJohn MeheganAndreia OliveiraLorenzo RichiardiMaria Pia FantiniSylvaine CordierFerran BallesterNina IszattHerman T. Den DekkerGreet SchoetersGreet SchoetersGreet SchoetersMonique MommersHazel InskipMikel BasterrecheaCarel ThijsRenate H. M. De GrootRenate H. M. De GrootAlet H. WijgaMarij GielenMaria JansenMaria JansenNikos StratakisNikos StratakisMerete EggesbøLiesbeth DuijtsSjurdur F. OlsenSjurdur F. OlsenEva GovartsForastiere FrancescoDavide GoriDaniela PortaSheryl L. Rifas-shimanCecily Kelleher

subject

MaleMediterranean dietEpidemiologyCHILDRENCohort Studies0302 clinical medicineFish Fruit and Other FoodSurveys and QuestionnairesSeafood consumptionPrevalence030212 general & internal medicineseafoodChildPrenatal Nutritional Physiological Phenomena2. Zero hungermedicine.diagnostic_testJAPANESE INFANTSGeneral Medicine3. Good healthEuropeMEDITERRANEAN DIETLUNG-FUNCTIONChild PreschoolRegression AnalysisFemaleGeneration RpregnancyFATTY-ACIDSmedicine.symptomallergic rhinitiCohort studyFish consumptionWHEEZEAsthma - ChildrenECZEMA03 medical and health scienceschildrenEnvironmental healthWheezeFatty Acids Omega-3medicineAnimalsHumansRespiratory soundsRespiratory SoundsAsthmaPRENATAL EXPOSUREfishPregnancyallergic rhinitisWheezingwheezingbusiness.industryWheezing; allergic rhinitis; asthma; children; fish; pregnancy; seafoodMATERNAL FOOD-CONSUMPTIONInfant NewbornInfantasthmamedicine.diseaseRhinitis AllergicUnited States030228 respiratory systemAllergic rhinitis - ChildrenRelative riskGENERATION RHuman medicinebusiness

description

Background: It has been suggested that prenatal exposure to n-3 long-chain fatty acids protects against asthma and other allergy-related diseases later in childhood. The extent to which fish intake in pregnancy protects against child asthma and rhinitis symptoms remains unclear. We aimed to assess whether fish and seafood consumption in pregnancy is associated with childhood wheeze, asthma and allergic rhinitis. Methods: We pooled individual data from 60 774 mother-child pairs participating in 18 European and US birth cohort studies. Information on wheeze, asthma and allergic rhinitis prevalence was collected using validated questionnaires. The time periods of interest were: infancy (0-2 years), preschool age (3-4 years), and school age (5-8 years). We used multivariable generalized models to assess associations of fish and seafood (other than fish) consumption during pregnancy with child respiratory outcomes in cohort-specific analyses, with subsequent random-effects meta-analyses. Results: The median fish consumption during pregnancy ranged from 0.44 times/week in The Netherlands to 4.46 times/week in Spain. Maternal fish intake during pregnancy was not associated with offspring wheeze symptoms in any age group nor with the risk of child asthma [adjusted meta-analysis relative risk (RR) per 1-time/week = 1.01, 95% confidence interval 0.97-1.05)] and allergic rhinitis at school age (RR = 1.01, 0.99-1.03). These results were consistently found in further analyses by type of fish and seafood consumption and in sensitivity analyses. Conclusion: We found no evidence supporting a protective association of fish and seafood consumption during pregnancy with offspring symptoms of wheeze, asthma and allergic rhinitis from infancy to mid childhood. This work was supported by the European Community’s Seventh Framework Program [EU- FP7- HEALTH-2009-single-stage-241604]. Details of funding per cohort are available at IJE online.

yearjournalcountryeditionlanguage
2017-10-01International Journal of Epidemiology
10.1093/ije/dyx007https://doi.org/10.1093/ije/dyx007