6533b855fe1ef96bd12afec9
RESEARCH PRODUCT
Antiproliferative effect of interferons on human prostate carcinoma cell lines.
L. CastagnettaL. FabbroniMichele Pavone-macalusoGigliola SicaM. Cacciatoresubject
Malemedicine.medical_specialtyUrologymedicine.medical_treatmentBiologyInterferon alpha-2law.inventionSteroidCell LineProstate cancerlawInterferonInternal medicinemedicineTumor Cells CulturedHumansReceptorFibroblastCell growthInterferon-alphaProstatic Neoplasmsmedicine.diseaseRecombinant ProteinsEndocrinologymedicine.anatomical_structureCell cultureInterferon Type ICancer researchRecombinant DNACell Divisionmedicine.drugdescription
The effect of purified human fibroblast beta-interferon (B-IFN) and recombinant alpha-2b-interferon (A-IFN) on cell proliferation was investigated in two human prostate carcinoma cell lines, named PC-3 and DU-145. Both cell lines respond to the antiproliferative action of interferon, B-IFN being more effective than A-IFN. PC-3 is more sensitive than DU-145 cell line, showing 95% inhibition of cell proliferation at the highest concentration of B-IFN. As interferons, besides reducing cell growth, are able to modify steroid receptor content in different hormone-sensitive human tumours, our results may be of some relevance as these drugs might be used to regulate both cell proliferation and hormone-sensitivity in prostate cancer.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-03-01 | Urological research |