6533b855fe1ef96bd12aff09

RESEARCH PRODUCT

N-acetylcysteine protects against age-related increase in oxidized proteins in mouse synaptic mitochondria.

Natividad Martı́nezAna Isabel HernándezMaría Luisa FerrándizMarcos Arturo Martínez Banaclocha

subject

medicine.medical_specialtyAgingAntioxidantmedicine.medical_treatmentProtein Carbonyl ContentMice Inbred StrainsMitochondrionBiologyAcetylcysteinechemistry.chemical_compoundMiceInternal medicineAge relatedmedicineAnimalsSulfhydryl CompoundsMolecular BiologyBrain agingchemistry.chemical_classificationNeuronsGeneral NeuroscienceGlutathioneFree Radical ScavengersGlutathioneAcetylcysteineMitochondriaEndocrinologychemistryBiochemistrySynapsesThiolFemaleNeurology (clinical)Oxidation-ReductionDevelopmental Biologymedicine.drug

description

Since it has been proposed that oxidized protein accumulation plays a critical role in brain aging, we have investigated the effect of a thiolic antioxidant on protein carbonyl content in synaptic mitochondria from female OF-1 mice. At 48 weeks of age, a control group was fed standard food pellets and another group received pellets containing 0.3% (w/w) of N-acetylcysteine. A 24-week treatment resulted in a significant decrease in protein carbonyl content in synaptic mitochondria of the N-acetylcysteine-treated animals as compared to age-matched controls.

yearjournalcountryeditionlanguage
1997-07-11Brain research
10.1016/s0006-8993(97)00493-9https://pubmed.ncbi.nlm.nih.gov/9262186