6533b855fe1ef96bd12aff3f
RESEARCH PRODUCT
Neurons as targets for T cells in the nervous system
Frauke ZippDaniel Gonzalez-duniaDaniel Gonzalez-duniaRoland S. LiblauHeinz Wiendlsubject
Nervous systemMultiple SclerosisT cell[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/NeurobiologyAntigen presentationCentral nervous systemInflammationAdaptive ImmunityBiology[SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]Nervous System03 medical and health sciences0302 clinical medicineT-Lymphocyte Subsets[SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]medicineAnimalsHumansEncephalitis Viral030304 developmental biologyNeuronsAntigen PresentationImmunity Cellular0303 health sciencesGeneral NeuroscienceHistocompatibility Antigens Class Iapoptosis[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/NeurobiologyT cellNeurodegenerative DiseasesAcquired immune systemcentral nervous systemneuron3. Good healthmedicine.anatomical_structurenervous system[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunologyinflammation[SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunologyencephalomyelitisNeuronNervous System Diseasesmedicine.symptomNeuroscience030217 neurology & neurosurgeryEx vivodescription
International audience; Accumulating evidence shows that T cells penetrate the central nervous system (CNS) parenchyma in several autoimmune, infectious, and degenerative neurological diseases. The structural and functional consequences for CNS neurons of their encounter with activated T cells have been investigated in several experimental systems, including ex vivo co-cultures, electrophysiology, and in vivo imaging. Here, we review the modalities of neuron/T cell interactions. We substantiate the contention that T cells are directly responsible for neuronal damage in a large number of neurological diseases and discuss mechanisms of neuronal damage mediated by distinct T cell subsets, the impact of which differs depending on the disease. Finally, we describe how a better understanding of the mechanisms at play offers new possibilities for therapeutic intervention.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-01 |