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RESEARCH PRODUCT

Effects of obesity on periodontal tissue remodeling during orthodontic movement.

Renata Cristina Lima SilvaAndressa Vilas Boas NogueiraPaulo Sérgio CerriCamila Chiérici MarcantonioRafael Scaf De MolonMaria Eduarda Scordamaia LopesJames DeschnerNatalia Da Ponte LeguizamónJoni Augusto Cirelli

subject

medicine.medical_specialtyMMP1Tooth Movement TechniquesPeriodontal LigamentGingivaAdipokineAdipose tissueOrthodonticsInflammationBone remodelingRats Sprague-Dawley03 medical and health sciences0302 clinical medicineInternal medicinemedicinePeriodontal fiberAnimalsObesityBone mineralbusiness.industry030206 dentistryX-Ray Microtomographymedicine.diseaseObesityRatsEndocrinologyBone Remodelingmedicine.symptombusiness030217 neurology & neurosurgery

description

Made available in DSpace on 2021-06-25T15:01:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) German Research Foundation (DFG) Introduction: Orthodontic movement triggers a sequence of cellular and molecular events that may be affected by different systemic conditions. This study evaluated the effect of obesity on rat periodontal tissue remodeling induced by mechanical orthodontic force. Methods: Thirty-two Holtzman rats were distributed into 4 groups: control, obesity induction (O), orthodontic movement (M), and obesity induction and orthodontic movement (OM). Obesity was induced by a high-fat diet for 90 days. After 15 days of orthodontic movement, the animals were killed. Obesity induction was confirmed by animal body weight, adipose tissue weight, and serologic analysis. Periodontal tissue remodeling was evaluated using microcomputed tomography and histologic analysis. The gene expression of adipokines and cytokines in gingival tissues was evaluated. Results: An increase in body and adipose tissue weight was observed in the obesity induction groups. The O group presented an increase in lipids and blood glucose. The OM group showed a decrease in bone volume fraction and bone mineral density compared with all other groups and a tendency for more rapid tooth movement than the M group. The OM group showed a higher quantity of inflammatory cells and higher Mmp1 expression than the O group. The O and OM groups showed higher Nampt expression than the control group and lower Nampt expression than the M group. Conclusions: Obesity modulates periodontal tissue remodeling during orthodontic movement and results in more inflammation and bone loss than in nonobese animals. (Am J Orthod Dentofacial Orthop Sao Paulo State Univ, Sch Dent Araraquara, Depat Diag & Surg, Rua Humaita1680, BR-14801903 Araraquara, SP, Brazil Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Periodontol & Operat Dent, Mainz, Rhineland Palat, Germany Sao Paulo State Univ, Sch Dent Araraquara, Dept Morphol, Araraquara, SP, Brazil Sao Paulo State Univ, Sch Dent Araraquara, Depat Diag & Surg, Rua Humaita1680, BR-14801903 Araraquara, SP, Brazil Sao Paulo State Univ, Sch Dent Araraquara, Dept Morphol, Araraquara, SP, Brazil FAPESP: 2016/00732-0 FAPESP: 2014/20715-7 FAPESP: 2017/01358-7 FAPESP: 2017/07137-2 German Research Foundation (DFG): 1593/5-1

yearjournalcountryeditionlanguage
2021-04-01American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
10.1016/j.ajodo.2019.12.025https://pubmed.ncbi.nlm.nih.gov/33563505