Interleukin-2 immediate type hypersensitivity?

6533b855fe1ef96bd12b0069

RESEARCH PRODUCT

Interleukin-2 immediate type hypersensitivity?

Jürgen Knop Peri Caucig Susanne Lescau Esther Von Stebut Marcus Maurer

subject

Interleukin 2 Adult Male medicine.medical_treatment Dermatology Immunoglobulin E Basophil degranulation law.invention law medicine Humans biology business.industry Degranulation Immunotherapy Middle Aged medicine.disease In vitro Immunology biology.protein Recombinant DNA Interleukin-2 Female Drug Eruptions business medicine.drug Type I hypersensitivity

description

Two patients with metastatic malignant melanoma developed immediate type hypersensitivity-like symptoms while being treated with recombinant interleukin-(IL-)2 immunotherapy. Both patients showed positive skin prick tests to IL-2, enhanced basophil degranulation in vitro and responded to anti-histamines, but laboratory investigations suggested an IgE-independent, pseudoallergic mast cell degranulation against IL-2.

year	journal	country	edition	language
2008-05-21	Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

10.1111/j.1610-0387.2008.06769.x https://pubmed.ncbi.nlm.nih.gov/18498378

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