6533b855fe1ef96bd12b006a
RESEARCH PRODUCT
Calpains promote α2β1 integrin turnover in nonrecycling integrin pathway
Liisa NissinenR. Holland ChengNina RintanenLassi PaavolainenPaula UplaJohanna IvaskaJohanna IvaskaAnita MäkiMikko KarjalainenKatri KallioVarpu MarjomäkiMoona LehkonenJonna Alankosubject
EndosomeIntegrinCD18Medical and Health SciencesCD49cCell LineCollagen receptorFocal adhesion03 medical and health sciencesCell Line TumorHumansMolecular Biology030304 developmental biology0303 health sciencesFocal AdhesionsTumorbiologyCalpain030302 biochemistry & molecular biologyCell MembraneCell BiologyArticlesBiological Sciences3. Good healthCell biologyEnterovirus B HumanProtein TransportIntegrin alpha MMembrane Traffickingbiology.proteinIntegrin beta 6Enterovirus BIntegrin alpha2beta1HumanDevelopmental BiologySignal Transductiondescription
A novel virus- and integrin clustering–specific pathway diverts integrin from its normal endo/exocytic traffic to a nonrecycling degradative endosomal route. Clustering of α2β1 integrin causes redistribution of the integrin to perinuclear endosomes, leading to enhanced integrin turnover promoted by calpains.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-02-01 | Molecular Biology of the Cell |