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RESEARCH PRODUCT
The HTR1B 861GC receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy.
Nina GrintschukArmin SzegediChristoph FehrNorbert DahmenIon AnghelescuChristoph KlawePeter SingerChristoph Hiemkesubject
AdultMaleRiskCandidate genemedicine.medical_specialtyGeneralized anxiety disorderGenotypeInternal medicineGermanymedicineHumansPsychiatryTemperamentBiological PsychiatryPsychiatric geneticsAllelesNarcolepsyDepressive Disorder MajorPolymorphism GeneticPanic disorderPanicmedicine.diseaseAnxiety DisordersPsychiatry and Mental healthAlcoholismPhenotypeCase-Control StudiesReceptors SerotoninReceptor Serotonin 5-HT1BAnxietyPanic DisorderChromosomes Human Pair 6Femalemedicine.symptomPsychologyAnxiety disorderNarcolepsydescription
Abstract The HTR1B receptor gene has been linked to antisocial alcoholism in a Finnish population and an American Indian tribe [Lappalainen et al., Arch. Gen. Psychiatry, 55 (1998) 989]. Using a candidate gene approach, we genotyped 209 patients with alcoholism, 108 patients with major depression, 32 patients with panic disorder, 50 patients with generalized anxiety disorder, 58 patients with narcolepsy and 74 healthy volunteers for the HTR1B 861G>C polymorphism. There was a higher frequency of the HTR1B 861G alleles among the alcohol-dependent patients as compared to the control subjects (χ 2 =4.02, d.f.=2, P =0.04). However, the association resulted from higher frequencies of the opposite alleles (HTR1B 861G), as originally reported by Lappalainen et al. (1998). Although the association in our study might be due to a type I error, the higher degree of HTR1B allele sharing within both populations could also argue for another alcoholism-relevant gene within the proximity of the HTR1B gene on human chromosome 6.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-12-06 | Psychiatry research |