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RESEARCH PRODUCT
Preparation and Characterization of Gold Nanorods Coated with Gellan Gum and Lipoic Acid
Gennara CavallaroPaola VarvaràMariano LicciardiLuigi Tranchinasubject
Materials sciencephotothermal therapy02 engineering and technologyengineering.material010402 general chemistry01 natural scienceslcsh:Technologylcsh:Chemistrychemistry.chemical_compoundCoatinggold nanorodGeneral Materials ScienceSurface chargeInstrumentationlcsh:QH301-705.5Fluid Flow and Transfer Processeslcsh:TProcess Chemistry and TechnologyPhotothermal effectGeneral Engineeringpolysaccharide coatingPhotothermal therapy021001 nanoscience & nanotechnologylipoic acidhyperthermiagold nanorodsGellan gumlcsh:QC1-9990104 chemical sciencesComputer Science ApplicationsLipoic acidChemical engineeringchemistrylcsh:Biology (General)lcsh:QD1-999Covalent bondlcsh:TA1-2040engineeringNanorod0210 nano-technologylcsh:Engineering (General). Civil engineering (General)lcsh:Physicsgellan gumdescription
Gold nanorods (AuNRs) can combine therapeutic hyperthermia with diagnostic features, representing a smart choice to address personalized cancer treatments. In this regard, a crucial quest is the selection of the right biocompatible coating agent able to stabilize them in the physiological environment, further endowing the possibility to load bioactive molecules and/or targeting moieties. Therefore, AuNRs optical properties can be successfully merged with advantageous materials features to obtain selective photothermal therapy (PTT) systems. Here, the natural materials lipoic acid (LA) and the polysaccharide gellan gum (GG) were chosen to prepare three types of stabilized gold nanorods, using LA (AuNRs/LA), a layered coating of LA and GG (AuNRs/LA,GG) or a newly synthesized covalent derivative of LA and GG (AuNRs/GG-LA). The samples displayed diverse stability and dispersibility. Hydrodynamic diameters and surface potential analyses confirmed the nanometric size (100&ndash
year | journal | country | edition | language |
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2020-11-24 |