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RESEARCH PRODUCT

Association of Toll-like receptors 2, 3, and 4 genes polymorphisms with periapical pathosis risk

İHsan YikilganHasan OruçoğluZeynep OcakFatih OzanÜLkü ÖZanKürşat ErHalil SahmanElif-aybala OktayOrçun Toptaş

subject

0301 basic medicinePathologymedicine.medical_specialtyRoot canalOdontologíaGastroenterologyPolymorphism Single NucleotideEndodontics03 medical and health sciences0302 clinical medicineInternal medicineGenetic predispositionMedicineHumansGenetic Predisposition to DiseaseAlleleReceptorGeneral DentistryGeneAllelesOral Medicine and PathologyPolymorphism Geneticbusiness.industryResearchPeriapical DiseasesToll-Like ReceptorsPeriapical Pathosis030206 dentistry:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludToll-Like Receptor 2Toll-Like Receptor 3Toll-Like Receptor 4TLR2030104 developmental biologymedicine.anatomical_structureOtorhinolaryngologyCase-Control StudiesUNESCO::CIENCIAS MÉDICASTLR3TLR4Surgerybusiness

description

Background: The aim of this study was to investigate the role of gene variations of Toll-like receptors (TLR) 2, 3, and 4 on genetic susceptibility to periapical pathosis. Material and Methods: One hundred patients were included in the study and divided into two groups as follows; Control Group (n=50) that have root canal treatment and no periapical lesion, Patient Group (n=50) that have root canal treatment and periapical lesion. TLR2 Arg753Gln, TLR3 (c.1377C/T) and TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped by using PCR-RFLP. Genotypical analysis of control and patient groups were investigated to disclose whether there is any association between periapical lesions and gene variations. Results: There are no significant statistical differences between control and patient groups according to TLR 2 and 4 gene sequence. On the contrary, CC allele detected 74% for TLR 3 in patient group, and this difference was found to be statistically significant ( p < 0.005). Conclusions: According to these results, it can be suggested that patients with Toll-like receptor 3 gene polymorphisms could be susceptible to periapical pathosis.

yearjournalcountryeditionlanguage
2016-01-01Medicina Oral, Patología Oral y Cirugía Bucal
10.4317/medoral.21081http://europepmc.org/articles/PMC4920452