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RESEARCH PRODUCT

A Confirmatory Study on the Mechanisms Behind Reduced P300 Waves in Depression

P. WagnerJoachim Röschke

subject

AdultMalePharmacologyAnalysis of VarianceDepressive Disorder Majormedicine.medical_specialtyCase-control studyMiddle AgedAudiologyP300 amplitudeEvent-Related Potentials P300Developmental psychologyPsychiatry and Mental healthEvent-related potentialLinear ModelsmedicineHumansFemalePsychologyDepression (differential diagnoses)

description

A single-trial analysis of event-related potentials (P300) of 21 depressives was performed in comparison with matched controls. The purpose was to confirm previous results revealing an overall reduction of the single-trial P300 amplitude in depression despite fewer elicited single-trial P300 waves in schizophrenics. The result of the present study is in line with our previous investigation implicating a general reduced P300 amplitude on single trials of depressive patients. Therefore, it appears possible to differentiate depressives and schizophrenics by measuring event-related potentials and applying a single-trial analysis of them.

yearjournalcountryeditionlanguage
2003-06-24Neuropsychopharmacology
https://doi.org/10.1038/sj.npp.1300139