6533b855fe1ef96bd12b1256
RESEARCH PRODUCT
Postoperative analgesic efficacy of peripheral levobupivacaine and ropivacaine: a prospective, randomized double-blind trial in patients after total knee arthroplasty.
Christian WernerFlorian HeidMaren BäresAndreas RümelinTim PiephoPhilipp DreesNicole MüllerMarkus Giesasubject
Malemedicine.medical_specialtymedicine.drug_classAnalgesicTotal knee arthroplastyWalkingFemoral nerveDouble-Blind MethodMedicineHumansRopivacaineProspective StudiesAnesthetics LocalArthroplasty Replacement KneeAgedLevobupivacainePain MeasurementAged 80 and overPain Postoperativebusiness.industryLocal anestheticRopivacaineAnalgesia Patient-ControlledNerve BlockMiddle AgedAmidesBupivacainePeripheralSurgeryAnalgesics OpioidAnesthesiology and Pain MedicineTreatment OutcomeOpioidLevobupivacainePatient SatisfactionAnesthesiaFemalebusinessFemoral Nervemedicine.drugdescription
BACKGROUND: Several previous trials have characterized the intra- and postoperative effects of the recently introduced local anesthetics, levobupivacaine and ropivacaine, for a variety of continuous peripheral nerve blocks. METHODS: We compared the analgesic efficacy of levobupivacaine 0.125% versus ropivacaine 0.2% via patient-controlled femoral nerve analgesia after total knee arthroplasty. In a double-blind, randomized, prospective design, 60 patients received femoral infusion with either substance. We analyzed postoperative local anesthetic consumption, pain scores, motor block, and opioid requirements over 72 h. RESULTS: Pain scores, motor block incidence, and opioid requirements were low and not different between the groups. Ropivacaine consumption in milligrams was 67% higher than that of levobupivacaine. CONCLUSIONS: Both levobupivacaine 0.125% and ropivacaine 0.2% provide similar analgesia after total knee arthroplasty with the latter being less potent.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-04-19 | Anesthesia and analgesia |