6533b855fe1ef96bd12b135c
RESEARCH PRODUCT
Unveiling the molecular basis of disease co-occurrence: towards personalized comorbidity profiles
Alfonso ValenciaVera PancaldiRafael Tabarés-seisdedosFatima Al-shahrourJosé M. FernándezSalvador CapellaHéctor TejeroJon Sánchez-valleDavid Juansubject
Molecular levelbusiness.industryInteraction networkCo-occurrenceMedicineIn patientDiseaseComputational biologybusinessmedicine.diseaseComorbiditydescription
AbstractComorbidity is an impactful medical problem that is attracting increasing attention in healthcare and biomedical research. However, little is known about the molecular processes leading to the development of a specific disease in patients affected by other conditions. We present a disease interaction network inferred from similarities in patients’ molecular profiles, which significantly recapitulates epidemiologically documented comorbidities, providing the basis for their interpretation at a molecular level. Furthermore, expanding on the analysis of subgroups of patients with similar molecular profiles, our approach discovers comorbidity relations not previously described, implicates distinct genes in such relations, and identifies drugs whose side effects are potentially associated to the observed comorbidities.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-09-30 |