Are diabetes and its medications risk factors for the development of COVID-19? Data from a population-based study in Sicily

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RESEARCH PRODUCT

Are diabetes and its medications risk factors for the development of COVID-19? Data from a population-based study in Sicily

Vincenza A. Allotta Matteo Monami G. Antonio Silverii Achille Cernigliaro Valentina Guarnotta Carla Giordano Michela Conti Enrica Vigneri Salvatore Scondotto Edoardo Mannucci

subject

Adult Male medicine.medical_specialty Adolescent Coronavirus disease 2019 (COVID-19)Endocrinology Diabetes and Metabolism Medicine (miscellaneous)030209 endocrinology & metabolism 030204 cardiovascular system & hematology Settore MED/13 - Endocrinologia Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Diabetes mellitus Diabetes mellitus.Case fatality rate Diabetes Mellitus Prevalence medicine Humans Hypoglycemic Agents Risk factor Young adult Child Sicily Aged Retrospective Studies Aged 80 and over Nutrition and Dietetics SARS-CoV-2 business.industry Incidence Incidence (epidemiology)COVID-19 Infant Retrospective cohort study Middle Aged medicine.disease El Niño COVID-19 case fatality Child Preschool COVID-19 incidence Female Cardiology and Cardiovascular Medicine business

description

Abstract Background and aims Diabetes mellitus (DM) has been associated with higher incidence of severe cases of COVID-19 in hospitalized patients, but it is unknown whether DM is a risk factor for the overall COVID-19 incidence. The aim of present study was to investigate whether there is an association of DM with COVID-19 prevalence and case fatality, and between different DM medications and risk for COVID-19 infection and death. Methods and results retrospective observational study on all SARS-CoV-2 positive (SARS-CoV-2+) cases and deaths in Sicily up to 2020, May 14th. No difference in COVID-19 prevalence was found between people with and without DM (RR 0.92 [0.79–1.09]). Case fatality was significantly higher in SARS-CoV-2+ with DM (RR 4.5 [3.55–5.71]). No diabetes medication was associated with differences in risk for SARS-Cov2 infection. Conclusions in Sicily, DM was not a risk factor for COVID-19 infection, whereas it was associated with a higher case fatality.

year	journal	country	edition	language
2021-02-01	Nutrition, Metabolism and Cardiovascular Diseases

https://doi.org/10.1016/j.numecd.2020.09.028