6533b855fe1ef96bd12b1506
RESEARCH PRODUCT
Effect of divalent cations on KCl- and noradrenaline-induced contractile responses in rat aorta after nifedipine treatment.
M.a. NogueraMaria Dolores IvorraM P D'ocónS. Chuliásubject
AgonistMalemedicine.medical_specialtyContraction (grammar)Nifedipinemedicine.drug_classCations DivalentVasodilator AgentsAorta ThoracicIn Vitro TechniquesTonic (physiology)DivalentPotassium ChlorideNorepinephrineNifedipineInternal medicinemedicine.arterymedicineAnimalsVasoconstrictor AgentsRats WistarPharmacologychemistry.chemical_classificationAortaChemistryCardiovascular AgentsRatsEndocrinologyVasoconstrictionCalciummedicine.symptomIsotonic SolutionsVasoconstrictionMuscle contractionmedicine.drugdescription
Abstract Nifedipine (1 μM) relaxed the sustained contractile responses induced by 1 μM noradrenaline or 60 mM KCl in rat aortic strips. After washing, a second addition of the spasmogens gave smaller tonic contractions than the first one. Even more, a third addition of KCl also gave a smaller contraction than the first one, but a complete recovery of the contractile response to noradrenaline was obtained by a third addition of this agonist. Application of cumulative amounts of Ca2+ or Ba2+ (2.4–24 mM) on the residual contraction in response to these agents after nifedipine treatment, but in the absence of the blocker, restored the magnitude of the contractile responses. Addition of cumulative amounts of Mg2+ (2.4–24 mM) did not modify or even relax the contractile responses to KCl and noradrenaline, respectively.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-07-31 | General pharmacology |