6533b855fe1ef96bd12b1a68

RESEARCH PRODUCT

The Terminal Complement Complex (TCC) in the Plasma of Patients with Type 1 Diabetes Mellitus. Relationship with Albumin Excretion Rate

G ScarantinoE GiardinaGiovanni TrioloD CasigliaBompiani Gd

subject

Type 1 diabetesmedicine.medical_specialtybiologybusiness.industryAlbuminHeparan sulfatemedicine.diseaseComplement systemPathogenesisDiabetic nephropathychemistry.chemical_compoundEndocrinologychemistryTerminal complement complexInternal medicinemedicinebiology.proteinAntibodybusiness

description

Increased TCC levels were found to be present in the plasma of patients with type 1 diabetes associated with the presence of anti-heparan sulfate antibodies and increased urinary excretion of albumin. The authors suggest a role of terminal complement activation in the pathogenesis of diabetic nephropathy.

yearjournalcountryeditionlanguage
1991-01-01
https://doi.org/10.1007/978-1-4615-3884-4_54