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RESEARCH PRODUCT
Endocytotic activity in epitheloid and Langhans’ giant cells
W. ThoenesK. H. Langersubject
Pathologymedicine.medical_specialtybiologyLanghans giant cellmedicine.diseaseEndocytosisFerritinMultinucleateGiant cellbiology.proteinmedicineSecretionMicropinocytosisNephritisdescription
In the experimental tubulo-interstitial (anti-basement membrane) nephritis in the rat, electron microscopic studies after the in vivo microinjection of native ferritin in areas of granulomatous inflammation near the surface of the kidney indicate that epitheloid and multinucleate Langhans’ giant cells are capable of endocytosis and particularly of micropinocytosis. This suggests the possibility that endocytotic activities as well as secretion phenomena are important in the immune defense mechanisms linked with these “specifically” developed cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1984-12-01 | Virchows Archiv B Cell Pathology Including Molecular Pathology |