6533b856fe1ef96bd12b1c5e
RESEARCH PRODUCT
In vitro activity of the new semi-synthetic polypeptide cilofungin (LY121019) against Aspergillus and Candida species.
A. HuangDonald ArmstrongH J SchmittH J SchmittEdward M. BernardF F Edwardssubject
Microbiology (medical)AntifungalAspergillusbiologymedicine.drug_classAntibioticsCilofunginGeneral Medicinebiology.organism_classificationPeptides CyclicIn vitroCorpus albicansSemi syntheticMicrobiologychemistry.chemical_compoundEchinocandinsInfectious DiseasesAspergilluschemistrymedicinePeptidesCandidadescription
The in vitro activity of cilofungin (LY121019), a new semi-synthetic antifungal agent was evaluated. Potent activity was seen against Candida albicans and Candida tropicalis, with almost identical MIC and MFC results, whereas no activity was seen against any isolates of Candida parapsilosis or three Aspergillus spp. However, MICs were dependent on medium and test conditions chosen. It is concluded that cilofungin has good activity against some medically important yeasts in vitro, and that its in vitro activity depends on the method used.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1990-09-01 | European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology |