Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell

6533b856fe1ef96bd12b1c88

RESEARCH PRODUCT

Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell

Manuela Labbozzetta Aro Vonjy Ramarosandratana Monica Notarbartolo Maurizio Sajeva Pietro Zito James A. Mccubrey Paola Poma

subject

<i>Kalanchoe beharensis</i>Cell lcsh:Medicine lcsh:RS1-441 Pharmaceutical Science Kalanchoe beharensi Drug resistance Article essential oil NF-κB law.invention lcsh:Pharmacy and materia medica 03 medical and health sciences 0302 clinical medicine Kalanchoe beharensis law multidrug resistance Cyphostemma juttae Drug Discovery medicine NF-kappaB Settore BIO/15 - Biologia Farmaceutica Essential oil acute myeloid leukemia cell 030304 developmental biology 0303 health sciences <i>Cyphostemma juttae</i>biology lcsh:R Myeloid leukemia Cyphostemma juttae biology.organism_classification medicine.disease Multiple drug resistance Leukemia medicine.anatomical_structure Biochemistry 030220 oncology & carcinogenesis Settore BIO/03 - Botanica Ambientale E Applicata Settore BIO/14 - Farmacologia Molecular Medicine Kalanchoe beharensis

description

Drug resistance remains a major challenge in the treatment of cancer. The multiplicity of the drug resistance determinants raises the question about the optimal strategies to deal with them. Essential oils showed to inhibit the growth of different tumor cell types. Essential oils contain several chemical classes of compounds whose heterogeneity of active moieties can help prevent the development of drug resistance. In the present paper, we analyzed, by gas chromatography-mass spectrometry the chemical composition of the essential oil of the leaves of Kalanchoe beharensis obtained by hydrodistillation and compared the chemical composition of its essential oil with that of Cyphostemma juttae. Our results demonstrated the anticancer and proapoptotic activities of both species against acute myeloid leukemia on an in vitro model and its multidrug resistant variant involving NF-&kappa

year	journal	country	edition	language
2019-08-26	Pharmaceuticals

10.3390/ph12030124 http://dx.doi.org/10.3390/ph12030124

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