6533b856fe1ef96bd12b1d76
RESEARCH PRODUCT
Time sequence and site of fluid accumulation in experimental neurogenic pulmonary edema.
B. KremerHücker HFrenzel HRichter Iesubject
MalePathologymedicine.medical_specialtyTime FactorsIntracranial PressurePulmonary EdemaHorseradish peroxidaseCapillary PermeabilityEdemamedicineAnimalsCraniocerebral TraumaLungHorseradish PeroxidaseFixation (histology)Alveolar WallbiologyChemistryAlveolar septumGeneral MedicineAnatomyrespiratory systemPulmonary edemamedicine.diseaseCapillariesRatsPulmonary AlveoliMicroscopy ElectronLymphatic systemIntercellular Junctionsbiology.proteinmedicine.symptomPerfusiondescription
The initial phase of pulmonary edema development following intracranial pressure elevation was studied by means of transmission electron microscopy. Using perfusion fixation and application of a blood tracer (HRP horseradish peroxidase) the time sequence and site of fluid leakage out of pulmonary vessels was demonstrated: - passage of edema fluid through intercellular clefts of alveolar capillary endothelium - edema accumulation in alveolar interstitial tissue - draining of edema fluid from the alveolar septum to the interstitium of terminal bronchioli and to lymphatic vessels. An early interepithelial fluid leakage out of the alveolar wall remains questionable.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1976-10-29 | Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie |