6533b856fe1ef96bd12b1e99

RESEARCH PRODUCT

Molecular Mechanisms Leading from Periodontal Disease to Cancer

Bartosz Kamil SobockiCharbel A. BassetBożena Bruhn-olszewskaPaweł OlszewskiOlga SzotKarolina Kaźmierczak-siedleckaMateusz GuziakLuigi NibaliAngelo Leone

subject

QH301-705.5periodontal diseaseReviewOdontologi<i>Porphyromonas gingivalis</i>Catalysisimmune responseInorganic ChemistrycancerHumansBiology (General)Physical and Theoretical ChemistryImmune responseQD1-999Molecular BiologySpectroscopyPeriodontal DiseasesCancerCancer och onkologiRANK ligandFusobacterium nucleatumReceptor Activator of Nuclear Factor-kappa B<i>Fusobacterium nucleatum</i>Organic ChemistryGeneral MedicineComputer Science ApplicationsChemistrytumorigenesisGene Expression RegulationDentistryCancer and OncologyTumorigenesisDisease ProgressionCytokinesMouth NeoplasmsPeriodontal diseasePorphyromonas gingivalisSignal Transduction

description

Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigating tumorigenesis. We also present evidence for potential links between the RANKL–RANK signaling axis as well as circulating cytokines/leukocytes and carcinogenesis. Due to the nonconclusive data associating periodontitis and cancer reported in the case and cohort studies, we examine clinical trials relevant to the topic and summarize their outcome.

yearjournalcountryeditionlanguage
2022-01-16
10.3390/ijms23020970http://hdl.handle.net/10447/534376