6533b856fe1ef96bd12b255f

RESEARCH PRODUCT

Leukemic Colony-Forming Cells in Acute Myeloblastic Leukemia: Maturation Hierarchy and Growth Conditions

R. MertelsmannArnold GanserArnold GanserW. OsterW. OsterWalter KnappJames D. GriffinFriedhelm HerrmannFriedhelm HerrmannAlbrecht LindemannAlbrecht LindemannB. Dörken

subject

education.field_of_studyAcute myeloblastic leukemiaPopulationCellPlacental tissueBiologymedicine.diseasechemistry.chemical_compoundmedicine.anatomical_structurechemistryIn vivoCancer researchmedicineProgenitor celleducationThymidineLeukemic Blasts

description

Despite their primitive morphological appearance, the majority of leukemic blasts in acute myeloblastic leukemia (AML) are end-stage, nonproliferating cells. Only a small subset of AML blasts are capable of a sufficient number of divisions to form colonies in semisolid medium [1, 2]. It has been suggested that these leukemic colony-forming cells (L-CFC) may act in vivo as progenitor cells to maintain the rest of the leukemic cell population [3, 4]. L-CFC share several properties with normal myeloid progenitor cells, including self-renewal potential and high thymidine suicide index [2, 3]. As in the case of normal myeloid progenitor cells (NMPC), colony growth of L-CFC from most patients requires exogenous colony-stimulating factors (CSF) which are routinely supplied by the addition of media conditioned by activated T cells, placental tissue, or media derived from various tumor cell lines, including GCT [5], MO [6], or 5637 [7].

yearjournalcountryeditionlanguage
1987-01-01
https://doi.org/10.1007/978-3-642-72624-8_41