6533b856fe1ef96bd12b25d5

RESEARCH PRODUCT

Blood Flow and Oxygen Supply to Human Mammary Carcinomas Transplanted into Nude Rats

subject

description

Tumor blood flow (TBF), by itself, greatly influences the efficiency of nonsurgical therapeutic modalities, especially chemotherapy and hyperthermia. Furthermore, TBF is one of the most important determinants of tumor tissue oxygenation in vivo, thus playing a relevant role in tumor growth kinetics and in the development of regressive changes. In addition, the oxygenation of tumor tissue strongly determines the efficiency of radiation therapy and to a certain extent, pharmacodynamics of some antiproliferative drugs. Despite the considerable information available for rodent tumor systems, there are only sporadic ireports on blood flow (Beaney et al., 1984, Johnson, 1976, Mantyla, 1979, Mantyla et al., 1982) and oxygen supply (Beaney et al., 1984, Muller- Klieser et al., 1981) in human tumors mostly derived from clinical observations rather than from systematic studies. Therefore, using an epigastric pouching technique in immune- deficient (rnu/rnu) rats, TBF and oxygen utilization were evaluated systematically in tissue- isolated human mammary tumor heterotransplants.