6533b856fe1ef96bd12b2647

RESEARCH PRODUCT

P53 and bcl-2 immunoexpression in patients with oral lichen planus a nd oral squamous cell carcinoma

Rebeca-estela Rojo-botelloElba-rosa Leyva-huertaConstantino Ledesma-montesElisa Vega-memije

subject

AdultMalePathologymedicine.medical_specialtymedicine.drug_classMonoclonal antibodyMalignancyYoung Adultstomatognathic systemmedicineCarcinomaHumansIn patientBasal cellGeneral DentistryAgedMouth neoplasmOral Medicine and Pathologybusiness.industryMiddle Agedmedicine.disease:CIENCIAS MÉDICAS [UNESCO]stomatognathic diseasesProto-Oncogene Proteins c-bcl-2OtorhinolaryngologyUNESCO::CIENCIAS MÉDICASCarcinoma Squamous CellImmunohistochemistryResearch-ArticleFemaleMouth NeoplasmsSurgeryOral lichen planusTumor Suppressor Protein p53businessLichen Planus Oral

description

Objective: The aim of this study was to determine by immunohistochemistry the presence and significance of p53 and bcl-2 proteins in oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC). Study Design: We used 21 cases diagnosed as OLP 16 diagnosed as OSCC and four normal gingival biopsies taken from healthy patients were used as controls. Slides were processed for immunohistochemistry using anti-p53 and anti-bcl-2 monoclonal antibodies. Results: We found p53 immunoexpression in 71.4� OLP cases and 6� .7� OSCC cases, with no immunoexpres: We found p53 immunoexpression in 71.4� OLP cases and 6� .7� OSCC cases, with no immunoexpresWe found p53 immunoexpression in 71.4� OLP cases and 6� .7� OSCC cases, with no immunoexpression in control cases. Bcl-2 was negative for all OLP and OSCC cases, and mild positivity was observed in normal tissue. We found significant correlation among p53 expression and OSCC malignancy. Conclusions: Our results suggest that TP53 system mainly promotes a hyperproliferative state by cell cycle arrest of the OLP epithelial cells for repairing damaged DNA nor apoptosis and that anti-apoptotic action of bcl-2 is not important in this disease.

yearjournalcountryeditionlanguage
2012-05-01
10.4317/medoral.18013http://hdl.handle.net/10550/59881