6533b856fe1ef96bd12b2668

RESEARCH PRODUCT

Novel Biodegradable Composite of Calcium Phosphate Cement and the Collagen I Mimetic P-15 for Pedicle Screw Augmentation in Osteoporotic Bone

Naureen KericMarc A. BrockmannVolker MailänderFlorian RingelAndrea FoelgerHarald KrenzlinChristopher BlaseChristoph Düber

subject

Collagen imusculoskeletal diseasesmedicine.medical_specialtyQH301-705.5OsteoporosisMedicine (miscellaneous)General Biochemistry Genetics and Molecular BiologyArticleInternal medicinemedicineOsteopontinBiology (General)Calcium phosphate cementBone mineralosteoporotic vertebral fracturesbiologyChemistrytechnology industry and agricultureImplant failurecalcium phosphate cementmedicine.diseasemusculoskeletal systemosteoporosispolymethylmethacrylateEndocrinologybiology.proteinOsteoporotic boneOsteocalcincollagen I mimetic P-15

description

Osteoporotic vertebral fractures often necessitate fusion surgery, with high rates of implant failure. We present a novel bioactive composite of calcium phosphate cement (CPC) and the collagen I mimetic P-15 for pedicle screw augmentation in osteoporotic bone. Methods involved expression analysis of osteogenesis-related genes during osteoblastic differentiation by RT-PCR and immunostaining of osteopontin and Ca2+ deposits. Untreated and decalcified sheep vertebrae were utilized for linear pullout testing of pedicle screws. Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry (DEXA). Expression of ALPI II (p &lt

yearjournalcountryeditionlanguage
2021-10-04Biomedicines
10.3390/biomedicines9101392https://www.mdpi.com/2227-9059/9/10/1392