6533b856fe1ef96bd12b2841

RESEARCH PRODUCT

Bis(imidazolium) salts derived from amino acids as receptors and transport agents for chloride anions

Belén AltavaLaura González-mendozaRoberto QuesadaJorge EscorihuelaElsa HernandoCristian VicentSantiago V. LuisM. Isabel Burguete

subject

General Chemical EngineeringChemistry OrganicSalt (chemistry)Medicinal chemistryChlorideCompostos orgànics Síntesichemistry.chemical_compoundmedicineLife ScienceOrganic chemistryPOPCVLAGchemistry.chemical_classificationLiposomeamino acidsOrganic Chemistrychloride anionsQuímica orgánicaGeneral ChemistryOrganische ChemieTransmembrane proteinAmino acidchemistryProton NMRbis(imidazolium)TitrationAminoàcidsmedicine.drug

description

The binding properties of bis(imidazolium) hosts 1a–c derived from amino acids towards different anions have been studied by 1H NMR titration experiments in 95 : 05 CD3CN : H2O at 303 K, ESI-MS and theoretical calculations. Among this family, the salt 1c showed a strong and high selectivity for chloride anions. Transmembrane chloride transport activity has also been studied for the three bis(imidazolium) based transporters in POPC liposome models, and compound 1a was identified as an active chloride/nitrate exchanger.

yearjournalcountryeditionlanguage
2015-04-01
10.1039/c5ra05880ehttp://hdl.handle.net/10259/5137