6533b856fe1ef96bd12b2867
RESEARCH PRODUCT
Drug delivery devices based on mesoporous silicate.
Gennara CavallaroPaola PierroFlaviano TestaFabio Salvatore PalumboLuigi PasquaRosario Aiellosubject
NaproxenAbsorption of waterMaterials scienceNitrogenPharmaceutical ScienceDiflunisalIbuprofenmesoporous materialsDrug Delivery SystemsNaproxenDrug StabilityMaterials TestingmedicineOrganosilicon CompoundsChromatographyX-RaysWaterGeneral MedicineIbuprofenDiflunisalThermogravimetryChemical engineeringSolubilityDrug deliveryThermogravimetryAluminum SilicatesAdsorptionMesoporous materialPorositymedicine.drugMesoporous silicateAluminumdescription
A mesoporous material based on aluminosilicate mixture was studied to investigate its ability to include drugs and then release them. Nonsteroidal anti-inflammatory agents such as diflunisal, naproxen, ibuprofen and its sodium salt have been used in this study. The preparation of the mesoporous material and its characterization by X-ray, N2 absorption-desorption isotherm, and thermogravimetry analysis have been described. Drug loading was performed by a soaking procedure. Drug-loaded matrices were characterized for entrapped drug amount, water absorption ability, and thermogravimetric behavior. Drug release studies also were performed at pH 1.1 and 6.8 mimicking gastrointestinal fluids. Experimental results showed that this type of matrix is able to trap the bioactive agents by a soaking procedure and, then, to release them in conditions mimicking the biological fluids. Also, the high affinity of these matrices for water makes them potentially biocompatible. Release data suggest that the matrix impregnated with diflunisal offers good potential as a system for the modified drug release.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-06-01 | Drug delivery |